Our Publications in RNA Degradation & Ribonucleases Field

Selected publications by Dr Ronald T. Raines  display the citations in PubMed

1: Garnett ER, Raines RT. Emerging biological functions of ribonuclease 1 and angiogenin. Crit Rev Biochem Mol Biol. 2022 Jun;57(3):244-260. doi: 10.1080/10409238.2021.2004577. Epub 2021 Dec 9. PMID: 34886717; PMCID: PMC9156540.

2: Windsor IW, Dudley DM, O’Connor DH, Raines RT. Ribonuclease zymogen induces cytotoxicity upon HIV-1 infection. AIDS Res Ther. 2021 Oct 26;18(1):77. doi: 10.1186/s12981-021-00399-z. PMID: 34702287; PMCID: PMC8549155.

3: Sayers J, Wralstad EC, Raines RT. Semisynthesis of Human Ribonuclease-S. Bioconjug Chem. 2021 Jan 20;32(1):82-87. doi: 10.1021/acs.bioconjchem.0c00557. Epub 2020 Dec 9. PMID: 33296182; PMCID: PMC7856262.

4: Eller CH, Raines RT. Antimicrobial Synergy of a Ribonuclease and a Peptide Secreted by Human Cells. ACS Infect Dis. 2020 Nov 13;6(11):3083-3088. doi: 10.1021/acsinfecdis.0c00594. Epub 2020 Oct 15. PMID: 33054163; PMCID: PMC7669604.

5: Kilgore HR, Latham AP, Ressler VT, Zhang B, Raines RT. Structure and Dynamics of N-Glycosylated Human Ribonuclease 1. Biochemistry. 2020 Sep 1;59(34):3148-3156. doi: 10.1021/acs.biochem.0c00191. Epub 2020 Jun 30. PMID: 32544330; PMCID: PMC7483697.

6: Shepard SM, Windsor IW, Raines RT, Cummins CC. Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A. J Am Chem Soc. 2019 Nov 20;141(46):18400-18404. doi: 10.1021/jacs.9b09760. Epub 2019 Nov 11. PMID: 31651164; PMCID: PMC7015663.

7: Hoang TT, Johnson DA, Raines RT, Johnson JA. Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress. J Biol Chem. 2019 Oct 11;294(41):15095-15103. doi: 10.1074/jbc.RA119.008491. Epub 2019 Aug 20. PMID: 31431502; PMCID: PMC6791309.

8: Windsor IW, Graff CJ, Raines RT. Circular zymogens of human ribonuclease 1. Protein Sci. 2019 Sep;28(9):1713-1719. doi: 10.1002/pro.3686. Epub 2019 Aug 6. PMID: 31306518; PMCID: PMC6699097.

9: Garnett ER, Lomax JE, Mohammed BM, Gailani D, Sheehan JP, Raines RT. Phenotype of ribonuclease 1 deficiency in mice. RNA. 2019 Aug;25(8):921-934. doi: 10.1261/rna.070433.119. Epub 2019 May 3. PMID: 31053653; PMCID: PMC6633200.

10: Ressler VT, Mix KA, Raines RT. Esterification Delivers a Functional Enzyme into a Human Cell. ACS Chem Biol. 2019 Apr 19;14(4):599-602. doi: 10.1021/acschembio.9b00033. Epub 2019 Mar 11. PMID: 30830748; PMCID: PMC6474803.

11: Ressler VT, Raines RT. Consequences of the Endogenous N-Glycosylation of Human Ribonuclease 1. Biochemistry. 2019 Feb 19;58(7):987-996. doi: 10.1021/acs.biochem.8b01246. Epub 2019 Jan 29. PMID: 30633504; PMCID: PMC6380942.

12: Hoang TT, Tanrikulu IC, Vatland QA, Hoang TM, Raines RT. A Human Ribonuclease Variant and ERK-Pathway Inhibitors Exhibit Highly Synergistic Toxicity for Cancer Cells. Mol Cancer Ther. 2018 Dec;17(12):2622-2632. doi: 10.1158/1535-7163.MCT-18-0724. Epub 2018 Oct 3. PMID: 30282811; PMCID: PMC6279581.

13: Thomas SP, Hoang TT, Ressler VT, Raines RT. Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor. RNA. 2018 Aug;24(8):1018-1027. doi: 10.1261/rna.065516.117. Epub 2018 May 10. PMID: 29748193; PMCID: PMC6049508.

14: Lomax JE, Eller CH, Raines RT. Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology. Biochem J. 2017 Jun 21;474(13):2219-2233. doi: 10.1042/BCJ20170173. PMID: 28495858; PMCID: PMC5660862.

15: Hoang TT, Smith TP, Raines RT. A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity. Angew Chem Int Ed Engl. 2017 Mar 1;56(10):2619-2622. doi: 10.1002/anie.201611446. Epub 2017 Jan 25. PMID: 28120377; PMCID: PMC5418131.

16: Hoang TT, Raines RT. Molecular basis for the autonomous promotion of cell proliferation by angiogenin. Nucleic Acids Res. 2017 Jan 25;45(2):818-831. doi: 10.1093/nar/gkw1192. Epub 2016 Dec 2. PMID: 27915233; PMCID: PMC5314776.

17: Thomas SP, Kim E, Kim JS, Raines RT. Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases. Biochemistry. 2016 Nov 22;55(46):6359-6362. doi: 10.1021/acs.biochem.6b01003. Epub 2016 Nov 8. PMID: 27806571; PMCID: PMC5148631.

18: Arnold U, Raines RT. Replacing a single atom accelerates the folding of a protein and increases its thermostability. Org Biomol Chem. 2016 Jul 12;14(28):6780-5. doi: 10.1039/c6ob00980h. PMID: 27336677; PMCID: PMC5070668.

19: Andersen KA, Smith TP, Lomax JE, Raines RT. Boronic Acid for the Traceless Delivery of Proteins into Cells. ACS Chem Biol. 2016 Feb 19;11(2):319-23. doi: 10.1021/acschembio.5b00966. Epub 2015 Dec 15. PMID: 26629587; PMCID: PMC4900815.

20: Eller CH, Chao TY, Singarapu KK, Ouerfelli O, Yang G, Markley JL, Danishefsky SJ, Raines RT. Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1. ACS Cent Sci. 2015 Jul 22;1(4):181-190. doi: 10.1021/acscentsci.5b00164. Epub 2015 Jul 13. PMID: 26405690; PMCID: PMC4571170.