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1: Jackson CP, Fang S, Benjamin SR, Alayi T, Hathout Y, Gillen SM, Handel JP, Brems BM, Howe JM, Tumey LN. Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester- containing ADC linkers. Bioorg Med Chem Lett. 2022 Nov 1;75:128953. doi: 10.1016/j.bmcl.2022.128953. Epub 2022 Sep 1. PMID: 36058468.
2: Fang S, Brems BM, Olawode EO, Miller JT, Brooks TA, Tumey LN. Design and Characterization of Immune-Stimulating Imidazo[4,5-c]quinoline Antibody-Drug Conjugates. Mol Pharm. 2022 Sep 5;19(9):3228-3241. doi: 10.1021/acs.molpharmaceut.2c00392. Epub 2022 Jul 29. PMID: 35904247.
3: Miller JT, Vitro CN, Fang S, Benjamin SR, Tumey LN. Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers. Bioconjug Chem. 2021 Apr 21;32(4):842-858. doi: 10.1021/acs.bioconjchem.1c00124. Epub 2021 Mar 31. PMID: 33788548.
4: Liu S, Shah DK. Physiologically Based Pharmacokinetic Modeling to Characterize the Effect of Molecular Charge on Whole-Body Disposition of Monoclonal Antibodies. AAPS J. 2023 Apr 28;25(3):48. doi: 10.1208/s12248-023-00812-7. PMID: 37118220.
5: Chang HP, Le HK, Shah DK. Pharmacokinetics and Pharmacodynamics of Antibody- Drug Conjugates Administered via Subcutaneous and Intratumoral Routes. Pharmaceutics. 2023 Apr 3;15(4):1132. doi: 10.3390/pharmaceutics15041132. PMID: 37111619.
6: Chang HP, Li Z, Shah DK. Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody- Drug Conjugate in Mice. Pharm Res. 2022 Jan;39(1):1-24. doi: 10.1007/s11095-021-03162-1. Epub 2022 Jan 19. PMID: 35044590.
7: Bussing D, Sharma S, Li Z, Meyer LF, Shah DK. Quantitative Evaluation of the Effect of Antigen Expression Level on Antibody-Drug Conjugate Exposure in Solid Tumor. AAPS J. 2021 Apr 15;23(3):56. doi: 10.1208/s12248-021-00584-y. PMID: 33856579.23: Chang HP, Cheung YK, Shah DK. Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE). J Clin Med. 2021 Mar 23;10(6):1332. doi: 10.3390/jcm10061332. PMID: 33807057; PMCID: PMC8004929.